Assistant Professor of Pathology and Laboratory Medicine
Robert Wood Johnson Medical School
Dr. Subhajyoti De completed his BS in engineering from the Indian Institute of Technology, Kharagpur, India before pursing a PhD from the University of Cambridge, UK in the laboratory of Prof. Sarah Teichmann. There he developed computational biology approaches to study genetic variations and mutational signatures associated with human genome evolution. As a Human Frontier Science Program Fellow in the group of Prof. Franziska Michor at Harvard University, Dr. De investigated cancer as a somatic evolutionary process. He was able to demonstrate that genetic and epigenetic abnormalities in cancer genomes show non-random, context-dependent patterns. In his independent laboratory, first at Univ. Cololorado and currently at the Rutgers Cancer Institute of New Jersey, Dr. De is investigating cancer as a complex, adaptive system using genomic, computational, and systems-level approaches. He is a recipient of NIH/NCI PSOC Trans-network Young Investigator award, and Webb-Waring Scholar award. His work has been supported by the NIH, United Against Lung Cancer Foundation and Boettcher Foundation.
Dr. De’s lab develops and employs computational genomics tools to understand the biology of cancer and apply that knowledge to improve early detection, stratification, and therapeutic opportunities for patients. The interests of the lab include single molecule sequencing, evolutionary dynamics of tumor, genomic instability, and non-coding mutations in cancer.